| Disease |
Causative/
contributory
role for
H. pylori |
Effect of H. pylori eradication |
Peptic Ulcer
Disease (PUD) |
Yes |
Reduces ulcer recurrence rate |
| Mucosa-associated lymphoid tissue (MALT) lymphoma |
Yes |
Partial or complete remission in more than half of patients |
| Uninvestigated dyspepsia |
Yes, in some patients |
Symptom improvement in some patients |
| Iron-deficiency anemia |
Likely |
May lead to anemia resolution when H. pylori is the cause |
| Idiopathic thrombocytopenic purpura |
Yes, in some patients |
Platelet counts improve after eradication |
| NSAID-induced ulcer |
Controversial;
perhaps only in naïve NSAID users |
May reduce ulcer incidence in Asian naïve-NSAID
users |
| Gastroesophageal reflux disease (GERD) |
Unlikely, at least for most patients; H. pylori may protect against GERD |
Uncertain |
